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Ozempic (semaglutide) is a once-weekly injection that helps treat Type 2 diabetes. You should inject it on the same day each week, at any time of the day. It can. Start Ozempic with a 0.25 mg subcutaneous injection (injection under the skin) once weekly for 4 weeks. The 0.25 mg dosage is intended for treatment initiation. You take Ozempic ® once-weekly with an Ozempic ® pen, as prescribed and instructed by your health care professional. Read the Medication Guide and Instructions for Use that.